生物统计学，分析支持 & 评价
概述
生物统计学，分析支持 & 评估(BASE)用作 the biostatistical and biomathematical shared resource for investigators in areas of basic science, 转化和临床研究设计, 数据分析, 建模和管理.
服务请求
Requests to BASE for consulting services for cancer center investigators are initiated by email to (电子邮件保护) 用一个完整的 基地单位咨询申请表.
dropin的咨询
上门咨询无需预约. 欢迎从上午11点开始旁听.m. 至下午1时.m. 每个星期五.
地点: 公共卫生学院26-070室
主要服务
生物统计学的使命是分析支持 & 评价(基地) Shared Resource is to provide comprehensive and high-quality biostatistics support to cancer-related research at the UCLA Health 约翰逊综合癌症中心 in the areas of basic and translational research, 临床试验和人口研究. BASE Shared Resource services to 癌症中心 members include statistical support for grant application, 数据分析, 研究结果的解释, 以及手稿准备. The BASE Shared Resource also supports two critical 癌症中心 committees: Protocol Review & Monitoring Committee (PRMC) by providing statistical review of clinical trials protocols, 和数据 & Safety Monitoring Board (DSMB) by providing statistical support for the implementation, 开展和监测肿瘤试验. 除了, the BASE Shared Resource collaborates closely with several campus informatics facilities to support data management for cancer studies. BASE faculty members also develop novel statistical methodology in response to the needs of 癌症中心 research projects to facilitate studies.
拨款准备指引
BASE faculty assist individual 癌症中心 investigators in grant preparation. 我们在研究设计(实验设计)方面提供一般指导, 测量, 等), 样本大小的计算和统计分析皇冠hga025的发展. 除了协助准备奖助金, BASE faculty are generally available to serve as co-investigators on grant applications and provide long term collaboration for funded projects.
长期研究合作
Collaboration on projects from inception (typically at the grant preparation stage) through final manuscript submissions. 为此，我们可以提供赠款准备方面的协助, 研究计划, data management oversight data analytic support and collaboration on manuscript preparation. Typically for long-term collaborations BASE faculty and staff will be involved on the grant application (or can be added to funded projects) with percent effort funding appropriate to their project responsibilities.
短期咨询
Provide a stable resource of productive biostatistical and biomathematical faculty and staff capable of short-term consulting with 癌症中心 members. Short-term consultation including 数据分析 以及手稿准备 are provided via recharge.
其他基本单元功能
- Provide critical expertise to protocol review and approval functions of the Internal Scientific Peer Review Committee (ISPRC), 数据安全和监测委员会(DSMB), the Internal Quality Assurance Committee and the Seed Grant Review Committee
- Develop graduate student participation in cancer-related studies supervised by BASE and provide training to fellows and faculty in the design and conduct of research
- Assist 癌症中心 and other specialized centers in their research and reporting functions
- Provide statistics short courses and seminars to interested groups within the 癌症中心
访问优先级
Biostatistical support is available to all 癌症中心 members and their laboratories. Peer-reviewed funded research projects of 癌症中心 investigators represent the highest priority.
充电率
An estimate of project costs will be provided after the initial consultation meeting. 癌症中心会员将获得百分之五的折扣.
BASE支持的选定项目
| PI | 试验名称 | 网站链接 |
|---|---|---|
| 安东尼里巴斯 | 干细胞基因重编程对抗癌症 | http://bit.ly/2OgkEhz |
| Linda Liau | 皇冠hga025大学洛杉矶分校脑癌孢子 | http://bit.ly/2OdkLKI |
| 罗伯特Reiter | 前列腺癌中的UCLA孢子 | http://urology.ucla.edu/spore |
| Avrum Spira, Denise Aberle, Steven Dubinett, David Elashoff, Marc Lenburg | 波士顿大学-皇冠hga025大学洛杉矶分校肺癌生物标志物开发实验室 | http://bit.ly/2E6GyyN |
| 乔纳森高盛 | A期1b/2随机, Open-Label Study of Niraparib Monotherapy or Niraparib Plus Temozolomide Versus Best Supportive Care as Maintenance Therapy in Patients with Extensive-Stage Small Cell Lung Cancer that had a Complete or Partial Response to Platinum-Based First-Line Chemotherapy (TRIO-US L-06) | |
| 蒂姆·克拉夫西，罗伯特·普林斯 | FDG PET反应临床试验 | |
| 罗山Bastani | Comparative Effectiveness of System Interventions to Increase HPV Vaccine Receipt in Federally Qualified Health Centers | |
| 帕特里夏·甘兹 | A Phase III Randomized Trial Targeting Behavioral Symptoms in Younger Breast Cancer Survivors |
选定的文件
Comparison of glioma-associated antigen peptide-loaded versus autologous tumor lysate-loaded dendritic cell vaccination in malignant glioma patients.
Efficacy of systemic adoptive transfer immunotherapy targeting NY-ESO-1 for glioblastoma
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma.
Targeted next-generation sequencing of 565 neuro-oncology patients at UCLA: A single institution experience.
Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma
正在进行的临床试验
派姆单抗的手术“机会之窗”和II期试验, 奥拉帕尼和替莫唑胺治疗复发性胶质母细胞瘤
Phase I surgical trial to evaluate early immunologic pharmacodynamic parameters for the PD-1 antibody pembrolizumab with autologous tumor lysatepulsed dendritic cell vaccination in patients with surgically accessible recurrent/progressive glioblastoma