Isla P. Garraway, MD, PhD

Areas of Research Interest:

• Prostate stem cells and development
  
• 前列腺上皮-间质相互作用
  
• 前列腺癌进展和转移的功能性生物标志物
  
• Prostate cancer health disparities
  
• Prostate cancer biorepositories
  
• 致死性前列腺癌的多基因组平台分析
  
• 数字图像分析在前列腺癌中的应用
  
• 前列腺肿瘤群体的单细胞测序

1. Miller, EM, Chamie, K, Kwan, L, Lewis, M, Knudsen, BS, and Garraway, IP*. 治疗对去势抵抗进展的影响, metastases, 以及局部高级别前列腺癌患者的死亡率. October, 2016, Cancer Medicine, PMID: 27997745; PMCID: PMC5269571.
2. Brennen, NW, Zhang, B, Kulac, I, Kisteman, N, Antony, L, Wang, H, DeMarzo, AM, Garraway, IP, Denmeade, SR, and Isaacs, JT. 人前列腺肿瘤转化过程中间充质干细胞的浸润. July 18, 2017, Oncotarget, PMID 28493842; PMCID: PMCID: 5564518.
3. Malihi, PD, Morikado, M, Welter, L, Liu, ST, Miller, ET, Cadaneanu, RM, Knudsen, BS, Lewis, MS, Carlsson, A, Velasco, CR, Kolatkar, A, Lee, MR, Garraway, IP, Hicks, J, and Kuhn, P. 诊断时单个前列腺癌细胞的形态蛋白质组学和拷贝数谱显示克隆多样性. Converg Sci Phys Oncol 2018;4:015003.PMID: 32670616
4. Rotinen, M, You, S, Yang, J, Coetzee, S, Huang, W-C, Huang, F, Pan, X, Yanez, A, Hazelett, D, Chu, C-Y, Chung, L, Freedland, S, DiVizio, D, Garraway, I, Murali, R, Knudsen, B, and Freeman, M. ONECUT2是一种可靶向的致死性前列腺癌主调节剂，可抑制雄激素轴. Submitted to Nature Medicine, Nov. 26, 2018. PMID: 30478421
5. Parikh NR, Huiza C, Patel JS, Tsai S, Kalpage N, Thein M, Pitcher S, Lee SP, Inouye WS, Jordan ML, Sanati H, Jafari L, Bennett CJ, Gin GE, Kishan AU, Reiter RE, Lewis M, Sadeghi A, Aronson WJ, Garraway IP, Rettig MB, Nickols NG. 系统性和肿瘤导向治疗寡转移性前列腺癌:针对新发寡转移性疾病退伍军人的II期试验研究方案. BMC Cancer. 2019 Apr 1;19(1):291. doi: 10.1186/s12885-019-5496-5.PMID: 30935383
6. Jan YJ, Yoon J, Chen JF, Teng PC, Yao N, Cheng S, Lozano A, Chu GCY, Chung H, Lu YT, Chen PJ, Wang JJ, Lee YT, Kim M, Zhu Y, Knudsen BS, Feng FY, Garraway IP, Gao AC, Chung LWK, Freeman MR, You S, Tseng HR, Posadas EM. 循环肿瘤细胞- rna检测评估转移性去势抵抗性前列腺癌雄激素受体信号抑制剂敏感性. Theranostics. 2019 Apr 13;9(10):2812-2826. doi: 10.7150/thno.34485. eCollection 2019.PMID: 31244925
7. Hughes RM, Simons BW, Khan H, Miller R, Kugler V, Torquato S, Theodros D, Haffner MC, Lotan T, Huang J, Davicioni E, An SS, Riddle RC, Thorek DLJ, Garraway IP, Fertig EJ, Isaacs JT, Brennen WN, Park BH, Hurley PJ. 阿司匹林限制间充质间质细胞分化和驱动转移进展. Cancer Res. 2019 Jul 15;79(14):3636-3650. doi: 10.1158/0008-5472.CAN-18-2931. Epub 2019 May 23. PMID: 31123087
8. Miller ET, You S, Cadaneanu RM, Kim M, Yoon J, Liu ST, Li X, Kwan L, Hodge J, Quist MJ, Grasso CS, Lewis MS, Knudsen BS, Freeman MR, Garraway IP. 未经治疗的前列腺癌的染色体不稳定性作为转移潜力的指标. BMC Cancer. 2020 May 7;20(1):398. doi: 10.1186/s12885-020-06817-1.PMID: 32380981
9. Kishan AU, Romero T, Alshalalfa M, Liu Y, Tran PT, Nickols NG, Ye H, Sajed D, Rettig MB, Reiter RE, Garraway IP, Spratt DE, Freedland SJ, Zhao X, Li Z, Deek M, Livingstone J, Mahal BA, Nguyen PL, Feng FY, Den RB, Schaeffer EM, Lotan TL, Karnes RJ, Klein EA, Ross AE, Grogan T, Davicioni E, Elashoff D, Boutros PC, Weidhaas JB. Gleason分级5组前列腺癌的转录组异质性. Eur Urol. 2020 May 24: S0302-2838(20)30349-3. doi: 10.1016/j.eururo.2020.05.009. Online ahead of print.PMID: 32461072
10. Lec PM, Lenis AT, Golla V, Brisbane W, Shuch B, Garraway I, Reiter R, Chamie KJ. 阿片及其受体在泌尿系统恶性肿瘤中的作用综述. J Urol. 2020 Jun 9:101097JU0000000000001156. doi: 10.1097/JU.0000000000001156. Online ahead of print.PMID: 32516030

Link to Dr. Garraway's PubMed publications

• Super Doctors® Southern California, 2022 - 2024
• 2018 Los Angeles Magazine Top Doctors
• Guy Dalla Riva Award 2004
• 2004年美国临床研究学会杰出研究奖
• Miley B. Wesson Proctor & 2003年美国大学西区赌博居民奖得主
• 2003年洛杉矶泌尿外科住院医师奖得主

Recent Grants:

• UCLA SPORE in Prostate Cancer (co-Investigator)
• 前列腺癌基金会挑战奖(首席研究员)
• 美国国防部前列腺癌研究项目创意奖(合作研究员)

• UCLA Department of Urology
• UCLA Cancer Center Profile
• UCLA Cancer Care Member Directory